Quality vs Quantity in European Universities
Just a quick note inspired by the World University Rankings 2014-15 published by The Times Higher Education. And restricted to European Countries. To get a better picture of how different Countries … Continue reading
The dual role of Transcription Factors in protein evolution, revisited
In December 2013, Stergachis and colleagues published a high-profile paper on the dual role Transcription Factors (TFs) might have as a consequence of their binding to protein coding regions. This observation could … Continue reading
No conservation of protein dynamics in enzyme evolution
Today’s #365papers is about the topics of protein dynamics, their role in enzymes and some insights into their role in evolution. Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering … Continue reading
An ‘invincible’ antibiotic that is bound to be defeated
The following paper was published as recently as yesterday, but already caused a bit of a stir on social media. Let’s see why. A new antibiotic kills pathogens without detectable … Continue reading
Give praise to DARPins
Today I’m briefly mentioning a recently published and very comprehensive Annual Review in Pharmacology and Toxicology: Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy Andreas Plückthun http://dx.doi.org/10.1146/annurev-pharmtox-010611-134654 … Continue reading
QM/MM analysis shows correlation between promiscuity and flexibility
To kick off my 2015 resolution, here’s a paper that uses molecular modelling to correlate the observed promiscuity profile of o-Succinylbenzoate Synthase with the involvement of alternative amino acids within the same active site. Enzyme Promiscuity … Continue reading
Resource allocation in Synthetic Biology [review]
What do you do to improve the efficiency of a system in which a key component P is used by multiple ‘effector’ mechanisms Si? At first, one might be tempted to … Continue reading
Fitness landscape analysis illuminates drug treatments [review]
An interesting manuscript in bioRxiv describes the computational analysis of fitness peaks in characterised drug-resistant bacteria to iterate the importance of ‘mixed drugs’ treatments. The use of more than one antibiotic … Continue reading
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